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irinotecan loaded lipid based nanovesicles

Based on

1 Articles
2015 Most recent source

Composition

1

Vacuous

Type
Formula
Role core
2

lipid film material

Type Complex Compound
Formula
Role layer
3

(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

irinotecan Camptosa CPT
Type Single Compound
Formula C33H38N4O6
Role loaded material
4

tumor-penetrating peptide

Type Biomolecule
Formula
Role layer
5

peptide

Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
cumulative amount of irinotecan leakage dependent on matrix metalloproteinase-2 presence

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Applications

Area Application Source
drug delivery

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
HT-29 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium
See all (4)
  1. INhjXE5APRH883b3X3zdijgngh2BvWi6WvllEO
Product

irinotecan loaded lipid based nanovesicles

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium
See all (4)
  1. AUXdV2u1Vq7zZSofeExBAMxsgZuXDIG5hZrJAY
Product

irinotecan loaded lipid based nanovesicles

References

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