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siRNA-PTX loaded PEG-pp-PEI-PE micelles

Based on

1 Articles
2014 Most recent source

Composition

1

(2-aminoethoxy)({2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy})phosphinic acid

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine 1,2-dioleoyl-sn-glycero-3-phosphatidyl-ethanolamine 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-dioleyl-sn-glycerophosphoethanolamine dioleoyl-phosphatidyl ethanolamine dioleoyl-phosphatidylethanol-amine dioleoylphosphatidylethanolamine DOPA DOPE
Type Single Compound
Formula C41H78NO8P
Role core
2

poly(iminoethylene)

polyethyleneimine polyaziridine PEI
Type Polymer
Formula
Role layer
3

MMP-2-cleavable peptide

Type Biomolecule
Formula
Role layer
4

poly(ethylene glycol)

poly(ethylene oxide) polyethylene glycol polyethylene oxide polyoxyethylene PEO PEG POE
Type Polymer
Formula
Role layer
5

siRNA

Type Biomolecule
Formula
Role layer
6

Paclitaxel

Plaxicel Abraxane Paxene Taxol PAC PCL PTX PX
Type Single Compound
Formula C47H51NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Source
stability in serum

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
A549 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • Hanks' balanced salt solution
  • PEG-pp-PEI-PE
  • Paclitaxel
Product

siRNA-PTX loaded PEG-pp-PEI-PE micelles

References

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