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dual-drug PLA-TPGS nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate

PLA-TPGS
Type Polymer
Formula
Role raw materials
2

docetaxel/tamoxifen mixture

DCL/TAM mixture
Type Complex Compound
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on drugs

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
breast cancer MCF7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • 2-{4-[(1Z)-1,2-diphenylpent-1-en-1-yl]phenoxy}ethyl)dimethylamine
  1. Md05YRGcD1NVjZR1YiFYd
Product

dual-drug PLA-TPGS nanoparticles

Hydrodynamic diameter: 191.3 - 192.9 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • 2-{4-[(1Z)-1,2-diphenylpent-1-en-1-yl]phenoxy}ethyl)dimethylamine
  1. xVsbEyQrzCFsMqvpsmh3o
Product

dual-drug PLA-TPGS nanoparticles

Hydrodynamic diameter: 175.5 - 180.9 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • 2-{4-[(1Z)-1,2-diphenylpent-1-en-1-yl]phenoxy}ethyl)dimethylamine
  1. MJrDhGwfyamyxs2dSxKe4
Product

dual-drug PLA-TPGS nanoparticles

Hydrodynamic diameter: 175.3 - 177.3 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • 2-{4-[(1Z)-1,2-diphenylpent-1-en-1-yl]phenoxy}ethyl)dimethylamine
  1. j2mHGMXCcX6YCearaCS2s
Product

dual-drug PLA-TPGS nanoparticles

Hydrodynamic diameter: 184.6 - 187.2 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate
  • 2-{4-[(1Z)-1,2-diphenylpent-1-en-1-yl]phenoxy}ethyl)dimethylamine
  1. GnfBnNOkhJMC9FuZHKYhx
Product

dual-drug PLA-TPGS nanoparticles

Hydrodynamic diameter: 178.6 - 182.2 nm

Medium: water

Support: none

References

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