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doxorubicin and microRNA-34a co-loaded hyaluronic acid-chitosan nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

sodium hyaluronate

HA
Type Biomolecule
Formula
Role raw materials
2

chitosan hydrochloride salt

CS
Type Biomolecule
Formula
Role raw materials
3

micro ribonucleic acid

microRNA-34a MiR-34a
Type Biomolecule
Formula
Role loaded material
4

doxorubicin hydrogen chloride

adriblastin hydrochloride doxorubicin hydrochloride adriamycin hydrochloride doxorubicin hydrochoride adriblastin HCl salt adriamycin HCl salt DOX hydrochloride DXR hydrochloride doxorubicin HCl DOX*HCl DOX-HCl DOX·HCl DXR HCl DXR*HCl Dox HCl Dox*HCl DOXS
Type Single Compound
Formula C27H29NO11*HCl
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female athymic nude BALB/c mouse bearing breast tumor

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • sodium hyaluronate
  • tripolyphosphate
  1. j72U2QswJb7IAE0eq
Product

doxorubicin and microRNA-34a co-loaded hyaluronic acid-chitosan nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
  1. KQj7ZAG5RJIZV
  2. yv9FSar
Product

doxorubicin and microRNA-34a co-loaded hyaluronic acid-chitosan nanoparticles

Size: ~ 225 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • sodium hyaluronate
  • tripolyphosphate
  1. HfDbci8Uyl4t02vsY
Product

doxorubicin and microRNA-34a co-loaded hyaluronic acid-chitosan nanoparticles

Size: 211 - 217 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  1. rzkvDmcl1ArRXDVkfQrQ6A9chOMe
  2. IgPHlP2
Product

doxorubicin and microRNA-34a co-loaded hyaluronic acid-chitosan nanoparticles

Size: ~ 230 nm

Medium: Roswell Park Memorial Institute medium 1640 with fetal bovine serum

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • sodium hyaluronate
  • tripolyphosphate
  1. QnFNHqBrqcrDHzRTg
Product

doxorubicin and microRNA-34a co-loaded hyaluronic acid-chitosan nanoparticles

Size: 184 - 202 nm

Medium: water

Support: none

References

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