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DOX-loaded tumor-extracellular matrix switched-on targeting liposomes

Based on

1 Articles
2014 Most recent source

Composition

1

ammonium sulfate solution

Type Complex Compound
Formula
Role core
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

1,2-dipalmitoyl-sn-glycero-phosphatidylcholine

dipalmitoyl phosphatidylcholine dipalmitoylphosphatidylcholine DPPC
Type Single Compound
Formula C40H80NO8P
Role layer
4

methoxy-poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide-co-histidine)-cholesterol copolymer

mPEG-P(HPMA-g-His)-cholesterol mPEG-b-P(HPMA-co-His)-Chol Poly_HP44His14
Type Polymer
Formula
Role loaded material
5

biotin2-polyethylene glycol crosslinker

biotin-polyethylene glycol-biotin biotin2-PEG crosslinker biotin2-PEG
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
drug leakage in serum

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Applications

Area Application Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Source
Balb-c/nude mouse with colon rectal cancer HCT116 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 1,2-dipalmitoyl-sn-glycero-phosphatidylcholine
  • methoxy-poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide-co-histidine)-cholesterol copolymer
  1. EUByv45nhkAA3pv46DlNdSDp
Product

DOX-loaded tumor-extracellular matrix switched-on targeting liposomes

References

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