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docetaxel-loaded PLA-TPGS/TPGS-COOH nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

PLA-TPGS/TPGS-COOH mixture

Type Complex Compound
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug release

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
SK-BR-3 cells

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Preparation

Method 1

Type: Physical formation
Source:
Product

docetaxel-loaded PLA-TPGS/TPGS-COOH nanoparticles

Method 2

Type: Physical formation
Source:
Product

docetaxel-loaded PLA-TPGS/TPGS-COOH nanoparticles

Method 3

Type: Physical formation
Source:
Starting materials
  • d-α-tocopheryl polyethylene glycol 1000 succinate-glutaric acid
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate
  1. DEDeRsO
Product

docetaxel-loaded PLA-TPGS/TPGS-COOH nanoparticles

Method 4

Type: Physical formation
Source:
Starting materials
  • d-α-tocopheryl polyethylene glycol 1000 succinate-glutaric acid
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate
  1. qrsOdyU
Product

docetaxel-loaded PLA-TPGS/TPGS-COOH nanoparticles

Method 5

Type: Physical formation
Source:
Starting materials
  • d-α-tocopheryl polyethylene glycol 1000 succinate-glutaric acid
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate
  1. jIcteGJ
Product

docetaxel-loaded PLA-TPGS/TPGS-COOH nanoparticles

References

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