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APRPG peptide-grafted TNP-470-loaded poly(ethylene glycol)-poly(lactic acid) nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

maleimide-PEG-PLA/mPEG-PLA mixture

Type Complex Compound
Formula
Role raw materials
2

(chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester

O-(chloroacetyl-carbamoyl)fumagillol TNP-470
Type Single Compound
Formula C19H28ClNO6
Role loaded material
3

Cys-Ala-Pro-Arg-Pro-Gly peptide

Type Single Compound
Formula C24H41N9O7S
Role graft

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human ovarian SKOV3 cancer-bearing female BALB/c mouse

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Preparation

Method 1

Type: Physical formation
Source:
Product

APRPG peptide-grafted TNP-470-loaded poly(ethylene glycol)-poly(lactic acid) nanoparticles

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  1. fCwHxD0itVxSuLp
Product

APRPG peptide-grafted TNP-470-loaded poly(ethylene glycol)-poly(lactic acid) nanoparticles

Size: not specified

Medium/Support: none

References

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