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GPC3 Ab-conjugated polyethylene glycol-linked siLuc-loaded polyethylene glycol-grafted chitosan polyethyleneimine copolymer/siloxane polyethylene glycol monolayer-coated iron oxide nanoparticles

Based on

1 Articles
2016 Most recent source

Composition

1

iron oxide

Type Single Compound
Formula FeO(x)
Role core
2

siloxane-polyethylene glycol

siloxane-PEG
Type Complex Compound
Formula
Role layer
3

PEG-grafted chitosan polyethyleneimine copolymer

CP-PEI
Type Polymer
Formula
Role layer
4

siLuc

Type Biomolecule
Formula
Role loaded material
5

poly(ethylene glycol)

poly(ethylene oxide) polyethylene glycol polyethylene oxide polyoxyethylene PEG PEO POE
Type Polymer
Formula
Role layer
6

GPC3

Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
rat RH7777 hepatocellular carcinoma cell line coexpressing human GPC3 (human glypican-3 receptor) and firefly luciferase-treated female athymic Nu/J mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • GPC3
  1. 9UtJFOsMcoPXOflpucLN2GqtXkoeXAt4KAGAsSQm8wWEU
  2. MjQw
Product

GPC3 Ab-conjugated polyethylene glycol-linked siLuc-loaded polyethylene glycol-grafted chitosan polyethyleneimine copolymer/siloxane polyethylene glycol monolayer-coated iron oxide nanoparticles

Hydrodynamic diameter: 40.61 - 41.43 nm

Medium: HEPES buffer

Support: none

References

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