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hyaluronic acid-coated drug-loaded mesoporous silica nanocapsules

Based on

1 Articles
2014 Most recent source

Composition

1

mesoporous silica nanocapsules

MSNC
Type Nano Material
Formula
Role core
2

(3-aminopropyl)-triethoxysilane moiety

(3-aminopropyl)trimethoxysilane moiety (3-aminopropyl)triethoxysilane moiety γ-aminopropyltriethoxy silane moiety 3-aminopropyltrimethoxysilane moiety 3-aminopropyltriethoxysilane moiety γ-aminopropyltriethoxysilane moiety (3-aminopropyl)trioxysilane moiety (3-aminopropyl)silanetrioxy group 3-aminopropylsilanetrioxy group 3-aminopropylsiloxy fragment 3-aminopropyl silane moiety 3-aminopropylsilane moiety γ-APTES moiety 3-APTS moiety APTES moiety APTMS moiety AMPS moiety APTS moiety APS moiety
Type Single Compound
Formula -C3H8NO3Si-
Role layer
3

MAL-PEG moiety

Type Polymer
Formula
Role layer
4

disulfide-functionalized hyaluronic acid

Type Complex Compound
Formula
Role layer
5

irinotecan hydrochloride trihydrate

CPT-11 CPT11
Type Single Compound
Formula C33H45ClN4O9
Role loaded material
6

tetradecafluorohexane

perfluorohexane PFH
Type Single Compound
Formula C6F14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
differential thermal analysis

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Biological effects

Biological system Test details Nanomaterial Variant Source
hepatocellular carcinoma HepG2 tumor-bearing nude mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  1. DqTc
  2. B0oZ
Product

hyaluronic acid-coated drug-loaded mesoporous silica nanocapsules

Hydrodynamic diameter: ~ 485 nm

Medium: ethanol

Support: none

References

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