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doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Based on

15 Articles
2017 Most recent source

Composition

1

doxorubicin-loaded poly(lactide-co-glycolide)-block-branched polyethyleneimine-block-poly(lactide-co-glycolide) nanoparticles

doxorubicin-loaded poly(lactide-co-glycolide)-block-branched polyethyleneimine-block-poly(lactide-co-glycolide) micelles DOX-loaded PLGA-b-bPEI-b-PLGA nanoparticles DOX-loaded PLGA-b-bPEI-b-PLGA micelles DOX-loaded cationic micelles
Type Nano Material
Formula
Role carriers
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
  1. 8iuvK6Qs5Wo0
  2. eFTY54Uqj
Product

doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
  1. 9xH9JKQIj5wMHy
  2. Gzf21SuBpGOtcQEZpUw
Product

doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • adriblastin
  • poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate)
  1. jiXJM08OSXtfFPVzkoMtjEsN4Msw
Product

doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Hydrodynamic diameter: 125 - 133 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Product

doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Hydrodynamic diameter: 111 - 125 nm

Medium: NaCl solution

Support: none

Method 5

Type: Physical formation
Source:
  1. 6vU2aR9xCnSJjf
  2. XTZXoP
  3. C2u6
Product

doxorubicin-loaded poly(ethylene glycol)-b-poly(ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolan-4-yl)methyl acrylate-co-2-(dimethylamino)ethyl methacrylate) micelles

Size: not specified

Medium/Support: none

References

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