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HCPT and Dox dual loaded SiO2-HCPT/Dox NP

Based on

1 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

10-hydroxycamptothecin

hydroxycamptothecin 10-HCPT HCPT CPT
Type Single Compound
Formula C20H16N2O5
Role core
2

silicon dioxide

silicic oxide silica
Type Single Compound
Formula SiO2
Role layer
3

(3-aminopropyl)-triethoxysilane moiety

(3-aminopropyl)trimethoxysilane moiety (3-aminopropyl)triethoxysilane moiety γ-aminopropyltriethoxy silane moiety 3-aminopropyltrimethoxysilane moiety 3-aminopropyltriethoxysilane moiety γ-aminopropyltriethoxysilane moiety (3-aminopropyl)trioxysilane moiety (3-aminopropyl)silanetrioxy group 3-aminopropylsilanetrioxy group 3-aminopropylsiloxy fragment 3-aminopropyl silane moiety 3-aminopropylsilane moiety γ-APTES moiety 3-APTS moiety APTES moiety APTMS moiety AMPS moiety APTS moiety APS moiety
Type Single Compound
Formula -C3H8NO3Si-
Role layer
4

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role layer

Properties

General physical and chemical properties

Property Value Source
drug release dependent on media

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Applications

Characterization

Method Source
transmission electron microscopy

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Biological effects

Biological system Test details Source
BALB/C mouse with cancer Colo-205 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  1. E0Qxx85J1HM7VQc1oCC
  2. WPssgVN
Product

HCPT and Dox dual loaded SiO2-HCPT/Dox NP

References

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