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Cy5.5-labeled cholesterol-conjugated siRNA-loaded high density lipoprotein mimicking peptide phospholipid nanoscaffold

Based on

1 Articles
2014 Most recent source

Composition

1

cholesteryl oleate

CO
Type Single Compound
Formula C43H74O2
Role core
2

1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide bis-oleate

fluorescent dye DiR-BOA DiR-BOA
Type Single Compound
Formula C61H93N2Br
Role loaded material
3

(2R)-2,3-bis(tetradecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate

1,2-dimyristoyl-sn-glycero-3-phosphocholine dimyristoyl-2-hydroxy-sn-glycero-3-phosphocholine 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine 1,2-dinonadecanoyl-sn-glycero-3-phosphocholine 1,2-dimyristoyl-sn-glycero-3- phosphocholine 1,2-dimyristoyl-sn-glycero-3-phosphocholine 2-dimyristoyl-sn-glycero-3-phosphocholine dimyristoyl-sn-glycero-3-phosphocholine L-α-dimyristoylphosphatidylcholine dimyristoyl phosphatidylcholine dimyristoylphosphatidylcholine di-14:0PC DMPC DMPE
Type Single Compound
Formula C36H72NO8P
Role layer
4

ApoA-1 mimetic peptide

Type Biomolecule
Formula
Role loaded material
5

Cy5.5 dye-labeled cholesterol-conjugated siRNA-bcl-2

Cy5.5-chol-si-bcl-2 Cy5.5-chol-siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Source
emission

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Applications

Characterization

Method Source
fluorescence spectroscopy

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Biological effects

Biological system Test details Source
athymic nude mouse bearing orthotopic PC3-luc6 tumor prostate cancer

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  1. 1RMpxshk7snorY3c
  2. MNU
Product

Cy5.5-labeled cholesterol-conjugated siRNA-loaded high density lipoprotein mimicking peptide phospholipid nanoscaffold

References

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