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doxorubicin-loaded siPlk1-coated lipid nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

N,N-distearyl-N,N-dimethylammonium bromide

dimethyl dioctadecylammonium bromide dimethyl distearyl ammonium bromide dimethyldioctadecylammonium bromide dioctadecyldimethylammonium bromide DODABr DODAB DDAB DOAB DODA DSAB DDA
Type Single Compound
Formula C38H80NBr
Role layer
3

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-poly(ethylene glycol)2000]

DSPE-PEG2000
Type Polymer
Formula
Role layer
4

small interfering RNA duplex

siRNA duplex
Type Biomolecule
Formula
Role layer
5

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
RNA-DOX release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c nude mouse bearing HeLa tumor

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-poly(ethylene glycol)2000]
  • N,N-distearyl-N,N-dimethylammonium bromide
  • doxorubicin
See all (4)
  1. ePlMgUkJh6np9gndY6u6yI90NSrOeb6
  2. UEz3CLjH4
Product

doxorubicin-loaded siPlk1-coated lipid nanoparticles

Hydrodynamic diameter: 143.7 nm

Medium/Support: none

References

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