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siPlk1-phospholipids enveloped hybrid nanoparticles dispersion in FBS-supplemented DMEM

Based on

1 Articles
2014 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

small interfering RNA duplex

siRNA duplex
Type Biomolecule
Formula
Role layer
3

N,N-distearyl-N,N-dimethylammonium bromide

dimethyl dioctadecylammonium bromide dimethyl distearyl ammonium bromide dimethyldioctadecylammonium bromide dioctadecyldimethylammonium bromide DODABr DODAB DDAB DOAB DODA DSAB DDA
Type Single Compound
Formula C38H80NBr
Role layer
4

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-poly(ethylene glycol)2000]

DSPE-PEG2000
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
confocal laser scanning microscopy

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Biological effects

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
Product

siPlk1-phospholipids enveloped hybrid nanoparticles dispersion in FBS-supplemented DMEM

Hydrodynamic diameter: ~ 135 nm

Medium: FBS-supplemented Dulbecco's modified Eagle medium

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy-poly(ethylene glycol)2000]
  • small interfering RNA duplex
  • N,N-distearyl-N,N-dimethylammonium bromide
See all (4)
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Product

siPlk1-phospholipids enveloped hybrid nanoparticles dispersion in FBS-supplemented DMEM

Hydrodynamic diameter: ~ 52 - ~ 147 nm

Medium/Support: none

References

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