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doxorubicin loaded HSPC/cholesterol/DSPE-PEG derived carboxylic acid nanoliposome

Based on

1 Articles
2015 Most recent source

Composition

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate

non-deuterated 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycerol-3-phosphatidylcholine 1,2-distearoyl-sn-glycero-3-phosphatidylcholine 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine L-α 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphorylcholine hydrogenated soy sn-glycero-3-phosphocholine 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-Distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphocholine hydrogenated soy L-α-phosphatidylcholine hydrogenated soybean phosphatidylcholine distearoyl-sn-glycero-3-phosphocholine hydrogenated soya phosphatidylcholine hydrogenated soy phosphatidylcholine Hydrogenated soy phosphatidylcholine hydrogenated L-α-phosphatidylcholine distearyl-L-α-phosphatidylcholine distearoyl phosphatidylcholine distearyl phosphatidyl choline distearoylphosphatidylcholine L-α-phosphatidylcholine egg PC hDSPC DSPC HSPC DSCP
Type Single Compound
Formula C44H88NO8P
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
4

1,2-distearoyl-sn-glycero-3-phosphatidylethanolamin-N-[carboxy(polyethylene glycol)] carboxylic acid

distearoyl phosphatidylethanolamine-N-[carboxy(polyethylene glycol)] carboxylic acid distearoylphosphatidylethanolamine-N-[carboxy(polyethylene glycol)] carboxylic acid DSPE-PEG-COOH
Type Polymer
Formula
Role loaded material
5

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
cryo-electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
HT1080 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • cholesterol
  • 1,2-distearoyl-sn-glycero-3-phosphatidylethanolamin-N-[carboxy(polyethylene glycol)] carboxylic acid
  1. pNmIw5UPMaKC2n7Ucj3
Product

doxorubicin loaded HSPC/cholesterol/DSPE-PEG derived carboxylic acid nanoliposome

Hydrodynamic diameter: 122.3 - 125.1 nm

Medium/Support: none

References

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