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epirubicin and pooled siRNA-encapsulated calcium phosphate particles

Based on

1 Articles
2015 Most recent source

Composition

1

calcium phosphate

CaP
Type Complex Compound
Formula
Role raw materials
2

water

Type Single Compound
Formula H2O
Role loaded material
3

epirubicin

EPIR EPI
Type Single Compound
Formula C27H29NO11
Role loaded material
4

small interfering ribonucleic acid

P-glycoprotein siRNA Pgp siRNA siRNA
Type Biomolecule
Formula
Role loaded material
5

small interfering ribonucleic acid

Bcl-2 siRNA siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
differential scanning calorimetry

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Biological effects

Biological system Test details Nanomaterial Variant Source
HepG2/ADM multiple drug resistant human liver cancer cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • small interfering ribonucleic acid
  • water
  • Dulbecco's modified Eagle medium
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Product

epirubicin and pooled siRNA-encapsulated calcium phosphate particles

Hydrodynamic size: ~ 60 nm

Size: 30 - 70 nm

Medium: Dulbecco's modified Eagle medium

Support: none

Method 2

Type: Physical formation
Source:
Product

epirubicin and pooled siRNA-encapsulated calcium phosphate particles

Size: 30 - 70 nm

Medium/Support: none

References

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