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doxorubicin and irinotecan-loaded Pluronic F127-PLGA nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

water

Type Single Compound
Formula H2O
Role core
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer

Pluronic F127 PF127
Type Polymer
Formula
Role layer
4

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role layer
5

(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

irinotecan Camptosa CPT
Type Single Compound
Formula C33H38N4O6
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug release dependent on drugs

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Applications

Characterization

Method Source
dynamic light scattering dependent on temperature

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Biological effects

Biological system Test details Source
human breast adenocarcinoma MDA-MB-231 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
  • water
  • poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer
See all (5)
  1. vvVEcpxn6yHYwYdXEJbXXJ5NFnY
  2. e3cnzQndJn
Product

doxorubicin and irinotecan-loaded Pluronic F127-PLGA nanoparticles

References

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