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cell penetrating poly(disulfide) capped doxorubicin loaded fluorescein isothiocyanate labeled mesoporous silica nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

mesoporous silica nanoparticles

MSN-PO4-
Type Nano Material
Formula
Role carriers
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

3',6'-dihydroxy-5-isothiocyanato-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one

fluorescein-5-isothiocyanate fluorescein isothiocyanate FITC
Type Single Compound
Formula C21H11NO5S
Role layer
4

cell penetrating poly(disulfide)

CPD
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on glutathione concentration

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HeLa cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 3-aminopropyltriethoxysilane
  • 3',6'-dihydroxy-5-isothiocyanato-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one
  1. CTnVlZMqlouEufKuXt
Product

cell penetrating poly(disulfide) capped doxorubicin loaded fluorescein isothiocyanate labeled mesoporous silica nanoparticles

Diameter: 120 nm

Medium/Support: none

References

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