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TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

cross-linked mannose-modified trimethyl chitosan-cysteine conjugate

cross-linked MTC conjugate
Type Biomolecule
Formula
Role raw materials
2

2'-O-methyl-modified TNF-α-specific siRNA duplex

tumor necrosis factor-alpha siRNA TNF-α siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Source
stability

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
scanning electron microscopy

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Biological effects

Biological system Test details Source
C57BL/6 mouse with DSS-induced ulcerative colitis (UC)

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • mannose-modified trimethyl chitosan-cysteine conjugate
  • 2'-O-methyl-modified TNF-α-specific siRNA duplex
  • pentasodium tripolyphosphate anhydrous
  1. UCrDa6skuix7vN2iu
  2. IIv8p
Product

TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • mannose-modified trimethyl chitosan-cysteine conjugate
  • 2'-O-methyl-modified TNF-α-specific siRNA duplex
  • pentasodium tripolyphosphate anhydrous
  1. njgMWFukQSyY2VWOL
  2. D1SGT
Product

TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • mannose-modified trimethyl chitosan-cysteine conjugate
  • 2'-O-methyl-modified TNF-α-specific siRNA duplex
  • pentasodium tripolyphosphate anhydrous
  1. q6MDZZcrO82pQSfXA
  2. iV6Xo
Product

TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

References

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