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TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

cross-linked mannose-modified trimethyl chitosan-cysteine conjugate

cross-linked MTC conjugate
Type Biomolecule
Formula
Role raw materials
2

2'-O-methyl-modified TNF-α-specific siRNA duplex

tumor necrosis factor-alpha siRNA TNF-α siRNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
C57BL/6 mouse with DSS-induced ulcerative colitis (UC)

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Preparation

Method 1

Type: Physical formation
Source:
Product

TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Hydrodynamic diameter: 146.2 - 151.0 nm

Medium: DLS medium

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • mannose-modified trimethyl chitosan-cysteine conjugate
  • 2'-O-methyl-modified TNF-α-specific siRNA duplex
  • pentasodium tripolyphosphate anhydrous
  1. TD6JKfFaH4jB4gXNc
  2. trnUg
Product

TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Product

TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Hydrodynamic diameter: 142.2 - 144.4 nm

Medium: DLS medium

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • mannose-modified trimethyl chitosan-cysteine conjugate
  • 2'-O-methyl-modified TNF-α-specific siRNA duplex
  • pentasodium tripolyphosphate anhydrous
  1. NMgvuHQA1wrDwQOua
  2. kEo0q
Product

TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Size: not specified

Medium/Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • mannose-modified trimethyl chitosan-cysteine conjugate
  • 2'-O-methyl-modified TNF-α-specific siRNA duplex
  • pentasodium tripolyphosphate anhydrous
  1. wBmzrwGgimP8QYnlD
  2. Ei2tg
Product

TNF-α siRNA-loaded mannose-modified trimethyl chitosan-cysteine conjugate nanoparticles

Size: not specified

Medium/Support: none

References

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