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Docetaxel-loaded lecithin-conjugate (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy(polyethylene glycol)2000-coated poly(d,l-lactic-co-glycolic acid nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

lecithin/1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine-poly(ethylene glycol) 2000

lecithin/DSPE-PEG 2000 lecithin/DSPE-PEG
Type Complex Compound
Formula
Role layer
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
green fluorescent protein-histone 2B (GFP-H2B)-transfected human epidermoid carcinoma cell line (KB)

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic-co-glycolic acid)
  1. tLjvDhrtwJz6XxPBVJBH6
Product

Docetaxel-loaded lecithin-conjugate (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy(polyethylene glycol)2000-coated poly(d,l-lactic-co-glycolic acid nanoparticles

Hydrodynamic diameter: 68 - 76 nm

Medium/Support: none

References

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