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docetaxel-loaded mPEG-PCL nanomicelles

Based on

1 Articles
2015 Most recent source

Composition

1

methoxypoly(ethylene glycol)

mPEG
Type Polymer
Formula
Role core
2

polycaprolactone

PCL
Type Polymer
Formula
Role layer
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Source
colloidal stability

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
female BALB/c mouse bearing B16-F10 melanoma

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone)
  1. ZYdeWzX1uxG4irA0BD43vXeIItcwe
Product

docetaxel-loaded mPEG-PCL nanomicelles

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone)
  1. 2Bsf96Lf5XLAhpKEYn540jTL80q4I
Product

docetaxel-loaded mPEG-PCL nanomicelles

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone)
  1. Cbny27cCLEN0WzqRrIcmgLd3LiPBW
Product

docetaxel-loaded mPEG-PCL nanomicelles

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone)
  1. 5JB72p8Oh7DjevH34hZqQ1C7cCHCN
Product

docetaxel-loaded mPEG-PCL nanomicelles

Method 5

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone)
  1. tzySqLgylNxUgIdp5ZaNYD9Wsequy
Product

docetaxel-loaded mPEG-PCL nanomicelles

References

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