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docetaxel, wortmannin-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer

PEG-PLGA
Type Polymer
Formula
Role raw materials
2

poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer

PEG-PLGA
Type Polymer
Formula
Role raw materials
3

wotrmannin

wotrmannin Wtmn
Type Single Compound
Formula C23H24O8
Role loaded material
4

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on drugs

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
H460 lung cancer cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • wotrmannin
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer
  1. cD4Q33ZRK3q9xRZCDsjHdUKK
  2. MtWteE
Product

docetaxel, wortmannin-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Diameter: 32 - 40 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • wotrmannin
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer
  1. ilIWSb9vIP6iyv6nO1DtUgpk
  2. 6SW7Us
Product

docetaxel, wortmannin-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
  1. eczG2J9VcTsAzwGZm
Product

docetaxel, wortmannin-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Diameter: 30 - 44 nm

Hydrodynamic diameter: 64 nm

Medium: phosphate buffer solution

Support: none

Method 4

Type: Physical formation
Source:
  1. 3xtwWbMANW2SchhKi
Product

docetaxel, wortmannin-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Diameter: 32 - 40 nm

Hydrodynamic diameter: 68 nm

Medium: phosphate buffer solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • wotrmannin
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer
  1. oOHsE8ldt9NzoWdDVMuj7A1p
  2. xTQy5l
Product

docetaxel, wortmannin-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Diameter: 30 - 44 nm

Medium/Support: none

References

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