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RGD-decorated polyurethane-polyurea roxithromycin-loaded nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

Crodamol GTCC

Type Complex Compound
Formula
Role core
2

1-isocyanato-3,3,5-trimethyl-5-isocyanatomethylcyclohexane

3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate isophorone di-isocyanate ester isophorone diisocyanate IPDI
Type Single Compound
Formula C12H18N2O2
Role layer
3

1,2-diaminoethane

ethylenediamine edamine
Type Single Compound
Formula C2H8N2
Role layer
4

poly(2,2'-disulfanediylbis(ethan-1-ol)-ran-1-isocyanato-3,3,5-trimethyl-5-isocyanatomethylcyclohexane-ran-(1-tris(hydroxymethyl)propane-g-methoxypoly(ethylene glycol)))-b-poly(N1-octadecylethane-1,2-diamine-co-1-isocyanato-3,3,5-trimethyl-5-isocyanatomethylcyclohexane)

Amphil
Type Polymer
Formula
Role layer
5

1,2-diaminoethane

ethylenediamine edamine
Type Single Compound
Formula C2H8N2
Role layer
6

cyclo(Arg-Gly-Asp-D-Phe-Lys)-labeled methoxypoly(ethylene glycol)

cRGDfK-labeled methoxypoly(ethylene glycol)
Type Polymer
Formula
Role layer
7

roxithromycin

Type Single Compound
Formula C41H76N2O15
Role loaded material
8

Clear Blue DFSB-C0

Type Complex Compound
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on media

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Applications

Area Application Nanomaterial Variant Source
implants

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
human osteogenic sarcoma Saos-2 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 1-isocyanato-3,3,5-trimethyl-5-isocyanatomethylcyclohexane
  • YMER N-120
  • 2-[(2-hydroxyethyl)disulfanyl]ethan-1-ol
See all (4)
  1. knO9GGbHocjVmlPo
  2. kJ1HSBPojUNvdcHa
  3. ucmD9E4
Product

RGD-decorated polyurethane-polyurea roxithromycin-loaded nanoparticles

Size: not specified

Medium: none

Support: amino-silanized titanium

References

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