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docetaxel-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer

PEG-PLGA
Type Polymer
Formula
Role raw materials
2

poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer

PEG-PLGA
Type Polymer
Formula
Role raw materials
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
H460 lung cancer cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer
  1. lk8BMGcXUfQo6QO2sXhk4bhm
  2. BwYzJ6
Product

docetaxel-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Diameter: 30 - 42 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
  1. voI5gnpnN2xdypsjD
Product

docetaxel-loaded poly(ethylene glycol)-co-poly(lactic-co-glycolic acid) diblock copolymer nanoparticles

Diameter: 30 - 42 nm

Hydrodynamic diameter: 63 nm

Medium: phosphate buffer solution

Support: none

References

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