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etoposide-loaded cationic self-microemulsifying drug delivery system

Based on

1 Articles
2015 Most recent source

Composition

1

Capmul MCM

Type Complex Compound
Formula
Role raw materials
2

polyoxyethylene (20) sorbitan monolaurate

Polysorbate 20 Alkest TW 20 Tween 20
Type Polymer
Formula
Role loaded material
3

poly(ethylene glycol)

poly(ethylene oxide) polyethylene glycol polyethylene oxide polyoxyethylene PEG PEO POE
Type Polymer
Formula
Role loaded material
4

mono-guanidine heterolipid

MGH
Type Single Compound
Formula C42H81N5O2
Role loaded material
5

4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]

etoposide VP-16 ETOP Etp
Type Single Compound
Formula C29H32O13
Role loaded material

Properties

General physical and chemical properties

Property Value Source
stability

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Applications

Area Application Source
drug delivery

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
C57BL/6 mouse with human melanoma B16F10 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • mono-guanidine heterolipid
  • 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]
  • Capmul MCM
Product

etoposide-loaded cationic self-microemulsifying drug delivery system

Method 2

Type: Physical formation
Source:
Starting materials
  • mono-guanidine heterolipid
  • 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]
  • Capmul MCM
Product

etoposide-loaded cationic self-microemulsifying drug delivery system

Method 3

Type: Physical formation
Source:
Starting materials
  • mono-guanidine heterolipid
  • 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]
  • Capmul MCM
Product

etoposide-loaded cationic self-microemulsifying drug delivery system

Method 4

Type: Physical formation
Source:
Starting materials
  • mono-guanidine heterolipid
  • 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]
  • Capmul MCM
Product

etoposide-loaded cationic self-microemulsifying drug delivery system

Method 5

Type: Physical formation
Source:
Starting materials
  • mono-guanidine heterolipid
  • 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]
  • Capmul MCM
Product

etoposide-loaded cationic self-microemulsifying drug delivery system

References

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