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CXCR4-targeted sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

D-α-tocopheryl polyethylene glycol 1000 succinate

TPGS
Type Polymer
Formula
Role layer
3

dioleoylphosphatydic acid

dioleoylphosphatydic acid DOPA
Type Single Compound
Formula C39H73O8P
Role layer
4

plerixafor

AMD3100
Type Single Compound
Formula C28H54N8
Role layer
5

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

sorafenib SFN SOR SF
Type Single Compound
Formula C21H16ClF3N4O3
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
C3H/HeNCrNarl mouse bearing HCA-1 tumor

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • D-α-tocopheryl polyethylene glycol 1000 succinate
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
  • dioleoylphosphatydic acid
See all (4)
  1. 82vm
Product

CXCR4-targeted sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Size: not specified

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • D-α-tocopheryl polyethylene glycol 1000 succinate
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
  • dioleoylphosphatydic acid
See all (4)
  1. 1bj9
Product

CXCR4-targeted sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Size: not specified

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • D-α-tocopheryl polyethylene glycol 1000 succinate
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
  • dioleoylphosphatydic acid
See all (4)
  1. 642Q
Product

CXCR4-targeted sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Size: 150 - 200 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Product

CXCR4-targeted sorafenib-loaded DOPA/TPGS-PLGA nanoparticles

Hydrodynamic diameter: 173.43 - 177.07 nm

Size: 150 - 200 nm

Medium: water

Support: none

References

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