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αVβ3-targeted fumagillin prodrug PFC nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

1

1-bromoheptadecafluorooctane

perfluorooctyl bromide perfluorooctylbromide perfluoroctylbromide PFOB
Type Single Compound
Formula C8BrF17
Role core
2

lecithin

Type Complex Compound
Formula
Role layer
3

αVβ3-integrin antagonist conjugated to PEG2000-phosphatidylethanolamine

Type Complex Compound
Formula
Role graft
4

fumagillin phospholipid prodrug

Fum-PD
Type Single Compound
Formula C49H90NO12P
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
male C57BL/6 mouse with KRN serum-induced arthritis

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • fumagillin phospholipid prodrug
  • αVβ3-integrin antagonist conjugated to PEG2000-phosphatidylethanolamine
  • lecithin
  1. fYrQ5bsqmneI11YjqHr
Product

αVβ3-targeted fumagillin prodrug PFC nanoparticles

Hydrodynamic diameter: 220 nm

Medium: water

Support: none

References

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