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5-fluorouracil-loaded lactobionic acid/glycyrrhetinic acid-modified chitosan-polyphosphate nanoparticle suspension

Based on

2 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

BEA zeolite

Type Complex Compound
Formula
Role carriers
2

5-fluoro-2,4(1H,3H)pyrimidinedione

5-Fluorouracil 5-fluorouracil fluorouracil Adrucil® Efudex® adrucil efudex 5-FU 5-Fu 5FU
Type Single Compound
Formula C4H3FN2O2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
differential scanning calorimetry

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Biological effects

Biological system Test details Nanomaterial Variant Source
5-fluorouracil-resistant human hepatocellular carcinoma SMMC-7721 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 5-fluoro-2,4(1H,3H)pyrimidinedione
  • glycyrrhetinic acid-modified chitosan
  • pentasodium tripolyphosphate anhydrous
  1. kdi1wj5xqWF
  2. 88bnbE8hKxIROBja
Product

5-fluorouracil-loaded lactobionic acid/glycyrrhetinic acid-modified chitosan-polyphosphate nanoparticle suspension

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

5-fluorouracil-loaded lactobionic acid/glycyrrhetinic acid-modified chitosan-polyphosphate nanoparticle suspension

Diameter: ~ 239.9 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • 5-fluoro-2,4(1H,3H)pyrimidinedione
  • chitosan
  • pentasodium tripolyphosphate anhydrous
  1. fkjHcaIvNmw
  2. 4dCWf9YRbvMFnziY
Product

5-fluorouracil-loaded lactobionic acid/glycyrrhetinic acid-modified chitosan-polyphosphate nanoparticle suspension

Size: not specified

Medium/Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • 5-fluoro-2,4(1H,3H)pyrimidinedione
  • lactobionic acid/glycyrrhetinic acid-modified chitosan
  • pentasodium tripolyphosphate anhydrous
  1. pdRyzszm1b3
  2. iOnADRPmU1dbokzq
Product

5-fluorouracil-loaded lactobionic acid/glycyrrhetinic acid-modified chitosan-polyphosphate nanoparticle suspension

Diameter: ~ 40 nm

Medium/Support: none

References

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