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PLGA-based CDDO-Me encapsulated nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

PLGA/PLGA-PEG mixture

Type Complex Compound
Formula
Role carriers
2

methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate

bardoxolone methyl CDDO-Me
Type Single Compound
Formula C32H43NO4
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
B16F10 tumor bearing C57BL/6 mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)-polyethylene oxide
  • methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
  • poly(lactic-co-glycolic acid)-polyethylene oxide-p-methoxybenzylamide
See all (4)
  1. xcvfWohj4IpbOiP
Product

PLGA-based CDDO-Me encapsulated nanoparticles

Hydrodynamic diameter: ~ 135 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)-polyethylene oxide
  • methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
  • poly(lactic-co-glycolic acid)-polyethylene oxide-p-methoxybenzylamide
See all (4)
  1. hqExhmjrQdNt5PU
Product

PLGA-based CDDO-Me encapsulated nanoparticles

Hydrodynamic diameter: ~ 100 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)-polyethylene oxide
  • methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
  • poly(lactic-co-glycolic acid)-polyethylene oxide-p-methoxybenzylamide
See all (4)
  1. 5GFq6EVPD6Y7Oc3
Product

PLGA-based CDDO-Me encapsulated nanoparticles

Hydrodynamic diameter: ~ 102 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)-polyethylene oxide
  • methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
  • poly(lactic-co-glycolic acid)-polyethylene oxide-p-methoxybenzylamide
See all (4)
  1. S2m5Tr1Si2NwSSs
Product

PLGA-based CDDO-Me encapsulated nanoparticles

Hydrodynamic diameter: ~ 115 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)-polyethylene oxide
  • methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
  • poly(lactic-co-glycolic acid)-polyethylene oxide-p-methoxybenzylamide
See all (4)
  1. j5zg0lL8Ld3n7As
Product

PLGA-based CDDO-Me encapsulated nanoparticles

Hydrodynamic diameter: ~ 106 nm

Medium: water

Support: none

References

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