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DOX-conjugated CBMA based NDV

Based on

1 Articles
2015 Most recent source

Composition

1

poly(3-[dimethyl({2-[(2-methylprop-2-enoyl)oxy]ethyl})azaniumyl]propanoate-co-methacryloylhydrazine-co-3-sulfopropyl methacrylate)

CBMA:MAH:SPM copolymer CBCP3
Type Polymer
Formula
Role raw materials
2

doxorubicin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role graft

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medical devices

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c nude mouse bearing BCap-37 breast cancer xenograft

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • doxorubicin hydrogen chloride
  • poly(3-[dimethyl({2-[(2-methylprop-2-enoyl)oxy]ethyl})azaniumyl]propanoate-co-methacryloylhydrazine-co-3-sulfopropyl methacrylate)
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Product

DOX-conjugated CBMA based NDV

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
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Product

DOX-conjugated CBMA based NDV

Hydrodynamic diameter: ~ 149 - ~ 176 nm

Medium: NaCl-Na2HPO4-citric acid solution

Support: none

Method 3

Type: Physical formation
Source:
Product

DOX-conjugated CBMA based NDV

Hydrodynamic diameter: 122 nm

Medium: phosphate buffer solution

Support: none

Method 4

Type: Physical formation
Source:
Product

DOX-conjugated CBMA based NDV

Hydrodynamic diameter: 201 nm

Medium: phosphate buffer solution

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • doxorubicin hydrogen chloride
  • poly(3-[dimethyl({2-[(2-methylprop-2-enoyl)oxy]ethyl})azaniumyl]propanoate-co-methacryloylhydrazine-co-3-sulfopropyl methacrylate)
  1. LsQ2cyzjDMzY0CvJDwr9lJ45Md4lUQIwN5mlNQjAC5D
  2. YWBq
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Product

DOX-conjugated CBMA based NDV

Size: not specified

Medium/Support: none

References

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