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PEG5K-Fmoc-VE2/camptothecin (vitamin E succinate bis(2-hydroxyethyl) disulfide ester) carbonate nanofibers

Based on

1 Articles
2015 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

PEG5K-Fmoc-VE2

Type Polymer
Formula
Role carriers
2

camptothecin (D-α-tocopherol succinate bis(2-hydroxyethyl) disulfide ester) carbonate

camptothecin (vitamin E succinate bis(2-hydroxyethyl) disulfide ester) carbonate CPT-S-S-VE
Type Single Compound
Formula C58H76N2O11S2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female 4T1.2 tumor-bearing BALB/c mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • camptothecin (D-α-tocopherol succinate bis(2-hydroxyethyl) disulfide ester) carbonate
  • PEG5K-Fmoc-VE2
  1. yRk
Product

PEG5K-Fmoc-VE2/camptothecin (vitamin E succinate bis(2-hydroxyethyl) disulfide ester) carbonate nanofibers

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • camptothecin (D-α-tocopherol succinate bis(2-hydroxyethyl) disulfide ester) carbonate
  • PEG5K-Fmoc-VE2
  1. Sgy
Product

PEG5K-Fmoc-VE2/camptothecin (vitamin E succinate bis(2-hydroxyethyl) disulfide ester) carbonate nanofibers

Hydrodynamic diameter: ~ 14.5 - ~ 112 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • camptothecin (D-α-tocopherol succinate bis(2-hydroxyethyl) disulfide ester) carbonate
  • PEG5K-Fmoc-VE2
  1. vIH
Product

PEG5K-Fmoc-VE2/camptothecin (vitamin E succinate bis(2-hydroxyethyl) disulfide ester) carbonate nanofibers

Hydrodynamic diameter: 73.7 - 89.3 nm

Medium: phosphate buffer solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • camptothecin (D-α-tocopherol succinate bis(2-hydroxyethyl) disulfide ester) carbonate
  • PEG5K-Fmoc-VE2
  1. ZFA
Product

PEG5K-Fmoc-VE2/camptothecin (vitamin E succinate bis(2-hydroxyethyl) disulfide ester) carbonate nanofibers

Hydrodynamic diameter: 53.4 - 61.8 nm

Medium: phosphate buffer solution

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • camptothecin (D-α-tocopherol succinate bis(2-hydroxyethyl) disulfide ester) carbonate
  • PEG5K-Fmoc-VE2
  1. 6Hk
Product

PEG5K-Fmoc-VE2/camptothecin (vitamin E succinate bis(2-hydroxyethyl) disulfide ester) carbonate nanofibers

Size: not specified

Medium: deuterated water

Support: none

References

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