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methotrexate - loaded poly(lactic-co-glycolic acid) gold (Au)/iron (Fe)/ gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid

Based on

1 Articles
2015 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role core
2

methotrexate

abitrexate folex MTX
Type Single Compound
Formula C20H22N8O5
Role loaded material
3

pluronic F-127

Type Polymer
Formula
Role partial layer
4

gold

Type Single Compound
Formula Au
Role partial layer
5

iron

Type Single Compound
Formula Fe
Role layer
6

gold

Type Single Compound
Formula Au
Role layer
7

SH-PEG-COOH

Type Polymer
Formula
Role layer
8

Deprotected cyclic RGDyK

cyRGD
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
inverse spin-spin relaxation time dependent on NIR irradiation

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
collagen induced arthritic male DBA/1J mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • pluronic F-127
  • poly(lactic-co-glycolic acid)
  • methotrexate
  1. yoR3ubNvPEl7hgWnQeeGogjnvVyHN7l6zvF
  2. 02M76JKm5bDRSri
Product

methotrexate - loaded poly(lactic-co-glycolic acid) gold (Au)/iron (Fe)/ gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid

Hydrodynamic diameter: ~ 135 nm

Thickness: 10 nm

Thickness: 5 nm

Medium: phosphate buffer solution

Support: none

References

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