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polymer/DSPC/cholesterol/PEG lipid/siRNA nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

lipocationic polymer

Type Polymer
Formula
Role core
2

poly(ethylene glycol) lipid

lipid polyethylene glycol PEG-lipid lipid PEG
Type Complex Compound
Formula
Role layer
3

[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate

non-deuterated 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycerol-3-phosphatidylcholine 1,2-distearoyl-sn-glycero-3-phosphatidylcholine 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine L-α 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphorylcholine hydrogenated soy sn-glycero-3-phosphocholine 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-Distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphocholine hydrogenated soy L-α-phosphatidylcholine hydrogenated soybean phosphatidylcholine distearoyl-sn-glycero-3-phosphocholine hydrogenated soya phosphatidylcholine hydrogenated soy phosphatidylcholine Hydrogenated soy phosphatidylcholine hydrogenated L-α-phosphatidylcholine distearyl-L-α-phosphatidylcholine distearoyl phosphatidylcholine distearyl phosphatidyl choline distearoylphosphatidylcholine L-α-phosphatidylcholine egg PC hDSPC DSPC HSPC DSCP
Type Single Compound
Formula C44H88NO8P
Role loaded material
4

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
5

siRNA against luciferase

siLuc
Type Biomolecule
Formula
Role loaded material

Properties

Applications

Area Application Source
drug delivery

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Characterization

Method Source
transmission electron microscopy

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Biological effects

Biological system Test details Source
HeLa-Luc cells

More information available to subscribers only.

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • lipocationic polymer
  • poly(ethylene glycol) lipid
  • cholesterol
See all (5)
  1. PAY2mscblttsrP0G
Product

polymer/DSPC/cholesterol/PEG lipid/siRNA nanoparticles

Method 2

Type: Physical formation
Source:
Starting materials
  • lipocationic polymer
  • poly(ethylene glycol) lipid
  • cholesterol
See all (5)
  1. N9S4ecK11S0qNcSr
Product

polymer/DSPC/cholesterol/PEG lipid/siRNA nanoparticles

Method 3

Type: Physical formation
Source:
Starting materials
  • lipocationic polymer
  • poly(ethylene glycol) lipid
  • cholesterol
See all (5)
  1. 0Z7Fai1f1JTLiTxE
Product

polymer/DSPC/cholesterol/PEG lipid/siRNA nanoparticles

Method 4

Type: Physical formation
Source:
Starting materials
  • lipocationic polymer
  • poly(ethylene glycol) lipid
  • cholesterol
See all (5)
  1. vbo3TRWz6p9w8gS4
Product

polymer/DSPC/cholesterol/PEG lipid/siRNA nanoparticles

Method 5

Type: Physical formation
Source:
Starting materials
  • lipocationic polymer
  • poly(ethylene glycol) lipid
  • cholesterol
See all (5)
  1. fGOCYW2Ei4rpYmft
Product

polymer/DSPC/cholesterol/PEG lipid/siRNA nanoparticles

References

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