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paclitaxel-loaded poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) micelles modified with YPSMA-1

Based on

1 Articles
2015 Most recent source

Composition

1

poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)

HOOC-PEOz-PLA
Type Polymer
Formula
Role raw materials
2

N-succinimide-modified poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)

NHS-PEOz-PLA
Type Polymer
Formula
Role raw materials
3

Paclitaxel

Plaxicel Abraxane Paxene Taxol PAC PCL PTX PX
Type Single Compound
Formula C47H51NO14
Role loaded material
4

anti-prostate specific membrane antigen antibody

YPSMA-1
Type Biomolecule
Formula
Role graft

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
22Rv1

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • N-succinimide-modified poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)
  • Paclitaxel
  • poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)
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Product

paclitaxel-loaded poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) micelles modified with YPSMA-1

Size: not specified

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • N-succinimide-modified poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)
  • Paclitaxel
  • poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)
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Product

paclitaxel-loaded poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) micelles modified with YPSMA-1

Diameter: 28.54 - 31.34 nm

Medium/Support: none

References

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