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pegylated poly-4-(vinylpyridine) nanoparticles laden with dexamethasone

Based on

1 Articles
1 Patents
2015 Most recent source

Composition

1

pegylated poly-4-(vinylpyridine)

PEG-PVPy
Type Polymer
Formula
Role carriers
2

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

dexamethasone Dex DEX DXM
Type Single Compound
Formula C22H29FO5
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug diffusion coefficient

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
New Zealand rabbit

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • pegylated poly-4-(vinylpyridine)
  1. JpiUa5K
  2. KJUvb
Product

pegylated poly-4-(vinylpyridine) nanoparticles laden with dexamethasone

Hydrodynamic diameter: 65.39 - 72.45 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • pegylated poly(D,L-lactic acid)
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  1. rUk
  2. 83YTNU2DaJ8u
Product

pegylated poly-4-(vinylpyridine) nanoparticles laden with dexamethasone

Hydrodynamic diameter: 60.04 - 62.82 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
Product

pegylated poly-4-(vinylpyridine) nanoparticles laden with dexamethasone

Hydrodynamic diameter: 31 - 59 nm

Medium: phosphate buffer solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • pegylated poly-4-(vinylpyridine)
  1. GhaffSw
  2. bcULq43FGHv5
Product

pegylated poly-4-(vinylpyridine) nanoparticles laden with dexamethasone

Hydrodynamic diameter: 40.08 - 49.38 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • pegylated poly-4-(vinylpyridine)
  1. 96n
  2. f84ffVC3mxoF
Product

pegylated poly-4-(vinylpyridine) nanoparticles laden with dexamethasone

Hydrodynamic diameter: 32.47 - 35.47 nm

Medium: water

Support: none

References

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