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loperamide hydrochloride-loaded poly-(lactic-co-glycolic) acid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role raw materials
2

4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidine butyramide monohydrochloride

loperamide hydrochloride
Type Single Compound
Formula C29H34Cl2N2O2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human blood

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidine butyramide monohydrochloride
  • poly(lactic-co-glycolic acid)
  1. ovWhVdAStLHvh
  2. Zzz2QyChUE7hcneIIxpDiI4pe
  3. pGrolPuflh2UEv0aKtrjAPOeZieU
Product

loperamide hydrochloride-loaded poly-(lactic-co-glycolic) acid nanoparticles

Hydrodynamic radius: 42 - 46 nm

Medium: veronal buffered saline

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidine butyramide monohydrochloride
  • poly(lactic-co-glycolic acid)
  1. KUhU4SBSujhL0
  2. Uq2qNS2uIZ2dtsPiK59NJdYvI
  3. 0Yg13fW6RDOFnnj0o5Ym6EUFuBeo
Product

loperamide hydrochloride-loaded poly-(lactic-co-glycolic) acid nanoparticles

Hydrodynamic radius: 269 - 293 nm

Medium: veronal buffered saline/human serum albumin

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidine butyramide monohydrochloride
  • poly(lactic-co-glycolic acid)
  1. xLaHGopAH4gfO
  2. 1tglB7oCsawPWm0D0i2Ajox6b
  3. bRzrKUo1XwYNFmrmcr580lAA4fIQ
Product

loperamide hydrochloride-loaded poly-(lactic-co-glycolic) acid nanoparticles

Hydrodynamic radius: 95 - 105 nm

Medium: phosphate buffer solution

Support: none

References

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