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nanoscale self-titrating activatable therapeutic

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

Vacuous

Type
Formula
Role core
2

heparin

Type Biomolecule
Formula
Role layer
3

cationic peptide

Type Biomolecule
Formula
Role layer
4

poly(ethylene glycol)-succinimidyl valerate moiety

PEG-SVA moiety
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
effective heparin activity

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
healthy female Swiss Webster mice

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • poly(ethylene glycol)-succinimidyl valerate
  • cationic peptide
  1. sLmHuAdPUpRXYlvm
Product

nanoscale self-titrating activatable therapeutic

Hydrodynamic diameter: ~ 150 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • poly(ethylene glycol)-succinimidyl valerate
  • cationic peptide
  1. KZpEexjR3g9kkhzs
Product

nanoscale self-titrating activatable therapeutic

Hydrodynamic diameter: ~ 145 nm

Medium: bovine serum

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • poly(ethylene glycol)-succinimidyl valerate
  • cationic peptide
  1. z8wGW7vkeBvBURa4
Product

nanoscale self-titrating activatable therapeutic

Hydrodynamic diameter: ~ 100 nm

Medium: phosphate buffer solution

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • poly(ethylene glycol)-succinimidyl valerate
  • cationic peptide
  1. a3weCmzbiEVbkpxu
Product

nanoscale self-titrating activatable therapeutic

Hydrodynamic diameter: ~ 65 nm

Medium: phosphate buffer solution

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • poly(ethylene glycol)-succinimidyl valerate
  • cationic peptide
  1. mZNlXRhVxQwrgfPb
Product

nanoscale self-titrating activatable therapeutic

Hydrodynamic diameter: ~ 75 nm

Medium: phosphate buffer solution

Support: none

References

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