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PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

mesoporous silica nanoparticles

MSNPs
Type Nano Material
Formula
Role core
2

(4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)

2',2'-difluoro-2'-deoxycytidine 2',2'-difluorodeoxycytidine gemcitabine gemzar dFdC GEM Gem
Type Single Compound
Formula C9H11F2N3O4
Role loaded material
3

DPPC/cholesteroll/DSPE-PEG

Type Complex Compound
Formula
Role layer
4

Paclitaxel

Plaxicel Abraxane Paxene Taxol PAC PCL PTX PX
Type Single Compound
Formula C47H51NO14
Role partial layer

Properties

General physical and chemical properties

Property Value Source
GEM release

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Applications

Area Application Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Source
athymic BALB/c nu/nu female mouse with orthotopic pancreatic PANC-1 tumor xenograft

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. x5h
  2. XAZd
  3. qVt6yua
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. liy
  2. xFr8
  3. uhUAyAQ
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. niq
  2. cZTl
  3. VIUO5rA
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. 51z
  2. gDAB
  3. 0P0GgdZ
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • water
  • silicic acid tetraethyl ester
  1. McI
  2. 1ZQu
  3. d8fGOql
Product

PTX/GEM-loaded liquid bilayer-coated mesoporous silica nanoparticles

References

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