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2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin

Type Single Compound
Formula C59H52N8O17S2
Role core
2

methoxy poly(ethylene glycol)-block-polylactide

mPEG-b-PLA
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
dithiothreitol-triggered drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HeLa cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  1. SHegoDimBy4EakATIVodBiWT3
  2. vTFEr7p9
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Diameter: ~ 120 - ~ 300 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  • water
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  2. WncKw2Dq
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Hydrodynamic diameter: 171 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  • water
  1. 93y1pEg2oZu2Uc
  2. aDZFCr9H
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Hydrodynamic diameter: 161 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  • water
  1. iHw3l5aNSEjdPf
  2. Jhgs801U
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Hydrodynamic diameter: 174 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  • water
  1. 5jwHRHGNxmoIGW
  2. I21ODZFC
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Hydrodynamic diameter: 159 nm

Medium: water

Support: none

References

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