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2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin

Type Single Compound
Formula C59H52N8O17S2
Role core
2

methoxy poly(ethylene glycol)-block-polylactide

mPEG-b-PLA
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
dithiothreitol-triggered drug release

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
HeLa cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  1. R3KSyQa3FELiiZaJPOvsdPmhn
  2. r4FNcuer
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Method 2

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  • water
  1. kbV2rHWfKxIRIx
  2. eiyoGTdH
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Method 3

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  • water
  1. 92jz9UO1qi5wGN
  2. nyOENDxp
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Method 4

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  • water
  1. ynFL59s4Aa53SR
  2. 5IZLdZ9F
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

Method 5

Type: Physical formation
Source:
Starting materials
  • 2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin
  • methoxy poly(ethylene glycol)-block-polylactide
  • water
  1. oGjzvntHaDxtj7
  2. 3l7T9yAX
Product

2-((2-(((3-azidopropoxy)carbonyl)oxy)ethyl)disulfanyl)ethyl (2,6-bis(hydroxymethyl)phenyl)carbamate-conjugated camptothecin-loaded mPEG-PLA nanoparticles

References

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