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poly(β-aminoester)/HSVtk DNA nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

poly(1,4-butanediol diacrylate-co-4-amino-1-butanol) end-modified with 1-(3-aminopropyl)-4-methylpiperazine

Type Polymer
Formula
Role carriers
2

pcDNA3.1-herpes simplex virus type 1 thymidine kinase DNA

pcDNA3.1-HSVtk DNA
Type Biomolecule
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
F344 rat bearing 9L gliosarcoma in presence of nucleoside analogue ganciclovir GCV

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • enhanced green fluorescent protein N1 plasmid DNA
  • poly(1,5-pentanediol diacrylate-co-3-amino-1-propanol) end-modified with 1-(3-aminopropyl)-4-methylpiperazine
  • phosphate buffer solution
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  2. Xf4KhZdyD
Product

poly(β-aminoester)/HSVtk DNA nanoparticles

Hydrodynamic diameter: 134 - 142 nm

Medium: phosphate buffer solution

Support: none

References

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