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DOX and CYC dual-drug loaded HA-SS-PLGA particles

Based on

1 Articles
2015 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

hyaluronic acid-cystamine-polylactic-co-glycolic acid

HA-SS-PLGA polymer HA-SS-PLGA
Type Polymer
Formula
Role carriers
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material
3

cyclopamine

CPA CYC CP
Type Single Compound
Formula C27H41NO2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
cyclopamine release dependent on redox environment

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer cell lines MCF-7

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Preparation

Method 1

Type: Physical formation
Source:
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Size: ~ 200 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Hydrodynamic diameter: ~ 200 - ~ 400 nm

Medium/Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • hyaluronic acid-cystamine-polylactic-co-glycolic acid
  • cyclopamine
  1. THUaMVznXo53hpiRAAvSKnL88O
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Hydrodynamic diameter: 293.6 - 303.2 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • hyaluronic acid-cystamine-polylactic-co-glycolic acid
  • cyclopamine
  1. oprXQpsxF59qJcO1opQqeDW4eB
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Hydrodynamic diameter: 261.6 - 279.6 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
  1. QDCuMatrduZV
Product

DOX and CYC dual-drug loaded HA-SS-PLGA particles

Hydrodynamic diameter: 225 nm

Medium: phosphate buffer solution

Support: none

References

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