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barbituric acid-loaded liposome-based mucus-penetrating particles

Based on

1 Articles
2015 Most recent source

Composition

1

water

Type Single Compound
Formula H2O
Role core
2

barbituric acid

BA
Type Single Compound
Formula C4H4N2O3
Role loaded material
3

[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate

non-deuterated 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycerol-3-phosphatidylcholine 1,2-distearoyl-sn-glycero-3-phosphatidylcholine 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine L-α 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphorylcholine hydrogenated soy sn-glycero-3-phosphocholine 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-Distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphocholine hydrogenated soy L-α-phosphatidylcholine hydrogenated soybean phosphatidylcholine distearoyl-sn-glycero-3-phosphocholine hydrogenated soya phosphatidylcholine hydrogenated soy phosphatidylcholine Hydrogenated soy phosphatidylcholine hydrogenated L-α-phosphatidylcholine distearyl-L-α-phosphatidylcholine distearoyl phosphatidylcholine distearyl phosphatidyl choline distearoylphosphatidylcholine L-α-phosphatidylcholine egg PC hDSPC DSPC HSPC DSCP
Type Single Compound
Formula C44H88NO8P
Role layer
4

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
5

rhodamine-labeled 18:1 PE

Type Single Compound
Formula C62H94N3O14P
Role loaded material

Properties

Applications

Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
CF-1 mouse

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • cholesterol
  • rhodamine-labeled 18:1 PE
  1. msrkb2e4wkKegwBGz6PX1k
  2. RJmVB4
  3. R0Rhpt4vccG4ArPY
Product

barbituric acid-loaded liposome-based mucus-penetrating particles

Hydrodynamic diameter: 101 - 125 nm

Medium: phosphate buffer solution

Support: none

References

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