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docetaxel 2'-O-(N-methyl-piperazinyl butanoic acid) ester-loaded distearoyl phosphatidylcholine/cholesterol liposomal nanoparticles

Based on

1 Patents
2012 Most recent source

Composition

1

docetaxel 2'-O-(N-methyl-piperazinyl butanoic acid) ester water solution

Type Complex Compound
Formula
Role core
2

hydrogenated soy L-α-phosphatidylcholine

hydrogenated soybean phosphatidylcholine hydrogenated soya phosphatidylcholine hydrogenated soy phosphatidylcholine distearoyl phosphatidylcholine distearoylphosphatidylcholine disteroylphosphatidyl choline L-α-phosphatidylcholine Phospholipon® 80H Soy PC DSPC HSPC SPC
Type Single Compound
Formula C44H88NO8P
Role layer
3

cholesterol

Type Single Compound
Formula C27H46O
Role layer
4

hydrogenated soy L-α-phosphatidylcholine

hydrogenated soybean phosphatidylcholine hydrogenated soya phosphatidylcholine hydrogenated soy phosphatidylcholine distearoyl phosphatidylcholine distearoylphosphatidylcholine disteroylphosphatidyl choline L-α-phosphatidylcholine Phospholipon® 80H Soy PC DSPC HSPC SPC
Type Single Compound
Formula C44H88NO8P
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug retention

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
female Swiss Webster mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 1-methyl piperazine
  • ethyl 4-bromobutanonate
  1. 7LqpCM5PgHatHxacnQmFIP2F
  2. sunPY5P
Product

docetaxel 2'-O-(N-methyl-piperazinyl butanoic acid) ester-loaded distearoyl phosphatidylcholine/cholesterol liposomal nanoparticles

Diameter: 80 - 120 nm

Medium/Support: none

References

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