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powder of particles containing itraconazole

Based on

1 Patents
2015 Most recent source

Composition

1

cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one

itraconazole
Type Single Compound
Formula C35H38Cl2N8O4
Role core
2

stearoyl polyoxyl-32 glyceride

Gelucire® 50/13
Type Complex Compound
Formula
Role layer

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  • stearoyl polyoxyl-32 glyceride
Product

powder of particles containing itraconazole

Hydrodynamic size: ~ 802 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  • stearoyl polyoxyl-32 glyceride
Product

powder of particles containing itraconazole

Hydrodynamic size: ~ 540 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  • stearoyl polyoxyl-32 glyceride
Product

powder of particles containing itraconazole

Hydrodynamic size: ~ 2387 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  • stearoyl polyoxyl-32 glyceride
Product

powder of particles containing itraconazole

Hydrodynamic size: ~ 1235 nm

Medium/Support: none

References

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