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PEI-PDHA/PEG-PDHA/PTX/siSna/siTwi

Based on

1 Articles
2015 Most recent source

Composition

1

HEPES buffer

Type Complex Compound
Formula
Role core
2

Paclitaxel

Plaxicel Abraxane Paxene Taxol PCL PAC PTX PX
Type Single Compound
Formula C47H51NO14
Role fillers
3

PEI-PDHA/PEG-PDHA mixture

Type Complex Compound
Formula
Role layer
4

Snail small interfering RNA

Snail siRNA siSna
Type Biomolecule
Formula
Role layer
5

Twist small interfering RNA

Twist siRNA siTwi
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c nude mouse with mouse breast tumor 4T1

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  1. yqYR
Product

PEI-PDHA/PEG-PDHA/PTX/siSna/siTwi

Hydrodynamic diameter: ~ 320 nm

Medium: FBS aqueous solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  1. 6Rfm
Product

PEI-PDHA/PEG-PDHA/PTX/siSna/siTwi

Hydrodynamic diameter: ~ 130 nm

Medium: FBS aqueous solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  1. ase6
Product

PEI-PDHA/PEG-PDHA/PTX/siSna/siTwi

Hydrodynamic diameter: ~ 125 nm

Medium: FBS aqueous solution

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • polyethyleneimine-block-poly[(1,4-butanediol)-diacrylate-β-5-hydroxyamylamine]
  • polyethylene glycol-block-poly[(1,4-butanediol)-diacrylate-β-5-hydroxyamylamine]
  • Paclitaxel
  1. judrePnsg4HtexHWLBDJ6nmeKO
  2. SbDd
Product

PEI-PDHA/PEG-PDHA/PTX/siSna/siTwi

Hydrodynamic diameter: ~ 80 - ~ 140 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  1. UmA8
Product

PEI-PDHA/PEG-PDHA/PTX/siSna/siTwi

Hydrodynamic diameter: ~ 240 nm

Medium: FBS aqueous solution

Support: none

References

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