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gemcitabine-Hypoxia-inducible factor 1 small interfering RNA-loaded lipid-polymer hybrid nanoparticles

Based on

1 Articles
2015 Most recent source

Composition

1

methylated polyethylene glycol-b-poly lactic-glycolic acid

mPEG-PLGA
Type Polymer
Formula
Role core
2

(4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)

2',2'-difluoro-2'-deoxycytidine 2',2'-difluorodeoxycytidine gemcitabine gemzar dFdC GEM Gem
Type Single Compound
Formula C9H11F2N3O4
Role loaded material
3

ε-polylysine

EPL
Type Biomolecule
Formula
Role layer
4

Hypoxia-inducible factor 1 small interfering RNA

HIF1α-siRNA
Type Biomolecule
Formula
Role layer
5

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(PEG)2000]

DSPE-PEG-2000
Type Polymer
Formula
Role layer
6

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material

Properties

Applications

Area Application Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Source
human pancreatic cancer luciferase expressing cells (panc-1-luc) orthotopic mouse xenografts

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • methylated polyethylene glycol-b-poly lactic-glycolic acid
  1. Qe1GDxECvY4mfudEDH
  2. IoG1d
  3. yQq3KsQLI8
Product

gemcitabine-Hypoxia-inducible factor 1 small interfering RNA-loaded lipid-polymer hybrid nanoparticles

References

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