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iRGD-modified PEG-PAMAM-cis-aconityl-DOX conjugate

Based on

1 Articles
2014 Most recent source

Composition

1

PAMAM dendrimer G4

Type Polymer
Formula
Role core
2

cis-aconitic anhydride-functionalized doxorubicin

doxorubicin-cis-aconityl unit DOX-cis-aconityl unit CA-DOX
Type Single Compound
Formula -C33H33N2O15
Role layer
3

β-mercaptoethanol-quenched N-hydroxysulfosuccinimide-PEG-maleimide unit

β-mercaptoethanol-quenched NHS-PEG-MAL unit
Type Polymer
Formula
Role layer
4

N-hydroxysulfosuccinimide-PEG-maleimide unit

NHS-PEG-MAL unit
Type Polymer
Formula
Role layer
5

tumor-penetrating peptide

internalizing RGD iRGD
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
glioma C6 cell spheroids

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Preparation

Method 1

Type: Physical formation
Source:
Product

iRGD-modified PEG-PAMAM-cis-aconityl-DOX conjugate

Hydrodynamic diameter: 19.04 - 21.18 nm

Medium: DLS medium

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • cis-aconityl-doxorubicin
  1. q6u
  2. 2EQjg8WcfTbZnhTSAdCPEEjUA
  3. YCXNt2Q8
Product

iRGD-modified PEG-PAMAM-cis-aconityl-DOX conjugate

Size: not specified

Medium/Support: none

References

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