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iRGD-modified PEG-PAMAM-cis-aconityl-DOX conjugate

Based on

1 Articles
2014 Most recent source

Composition

1

PAMAM dendrimer G4

Type Polymer
Formula
Role core
2

cis-aconitic anhydride-functionalized doxorubicin

doxorubicin-cis-aconityl unit DOX-cis-aconityl unit CA-DOX
Type Single Compound
Formula -C33H33N2O15
Role layer
3

β-mercaptoethanol-quenched N-hydroxysulfosuccinimide-PEG-maleimide unit

β-mercaptoethanol-quenched NHS-PEG-MAL unit
Type Polymer
Formula
Role layer
4

N-hydroxysulfosuccinimide-PEG-maleimide unit

NHS-PEG-MAL unit
Type Polymer
Formula
Role layer
5

tumor-penetrating peptide

internalizing RGD iRGD
Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source

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Applications

Area Application Source

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Characterization

Method Source

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Biological effects

Biological system Test details Source

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • cis-aconityl-doxorubicin
  1. rzV
  2. 5VAw45ar4JM8C6814J0yf4M7F
  3. 8ayDWzkk
Product

iRGD-modified PEG-PAMAM-cis-aconityl-DOX conjugate

References

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