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bortezomib-loaded Ald-PEG-PLGA NP

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

Ald-PEG-PLGA NP

Ald-PP NP
Type Nano Material
Formula
Role carriers
2

pyrazylcarbonyl-Phe-Leuboronate

bortezomib Bortezomib Velcade PS-341 BTZ
Type Single Compound
Formula C19H25BN4O4
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
biomimetic calcium phosphate binding

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c bearing human multiple myeloma MM1S cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. 9rmK
  2. KufKp6uNyalD
  3. 7fKX1G
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 98 nm

Medium: Hepes buffer

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. Uza8
  2. TaHM6BqNX7ky
  3. 8R43b4
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 68 nm

Medium: Hepes buffer

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. GiDV
  2. kYFn66t5HD
  3. V1v2Kp
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 250 nm

Medium: Hepes buffer

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. fP2X
  2. UN5zFDwm5p
  3. KCzFHa
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 190 nm

Medium: Hepes buffer

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • PLGA-b-PEG
  • pyrazylcarbonyl-Phe-Leuboronate
  • alendronate-conjugated polymer
  1. VaaO
  2. qDEM1lIc54PQ
  3. e7tzvg
Product

bortezomib-loaded Ald-PEG-PLGA NP

Hydrodynamic diameter: ~ 91 nm

Medium: Hepes buffer

Support: none

References

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