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doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Based on

8 Articles
2016 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

poly(ethylene glycol)-poly(D,L-lactide) block copolymer

mPEG-PCL diblock copolymer PEG5-PLA5 copolymer PEG5-PLA5 mPEG-PCL
Type Polymer
Formula
Role raw materials
2

adriblastin

adriblastin adriamycin DOX DXR
Type Single Compound
Formula C27H29NO11
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c mouse with breast cancer 4T1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • adriblastin
  • poly(ethylene glycol)-block-poly(D,L-lactide)
  1. YhCOYtOPJvepoq4UXqSOC5286wD
  2. 3mv1F
  3. Yl6cMS6kDnZxYbO
  4. jjmVzZb
  5. nHjOV8tszXN2wTawFltuazKzrCeHwdwg8
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Hydrodynamic diameter: 114.9 - 121.7 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • polyethylene glycol-block-poly(D,L-lactide)
  • adriblastin
  1. tbD0
  2. uPs1ObDud7hGRBhRP0Qm
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Diameter: 68 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • polyethylene glycol-block-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)
  • adriblastin
  1. Uzij
  2. 9ovYSYiRpPboSzz0B04A
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Diameter: 68 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • adriblastin
  • poly(ethylene glycol)-poly(D,L-lactide) block copolymer
  • water
  1. 5Ft
  2. jnT0jEo1
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Size: 42.73 - 49.67 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • adriblastin
  • poly(ethylene glycol)-poly(D,L-lactide) block copolymer
  • water
  1. 8nA
  2. bOb6CmMz
Product

doxorubicin-loaded poly(ethylene glycol)-poly(D,L-lactide) copolymer micelles

Size: 45.47 - 58.13 nm

Z-average size: ~ 50 nm

Medium: water

Support: none

References

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