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prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Based on

1 Patents
2014 Most recent source

Composition

1

PLGA-mPEG5K

Type Polymer
Formula
Role core
2

poly(lactide-co-glycolic acid)-polyethyleneglycol-S,S-2[3-][5-amino-1-carboxypentyl]-ureido]-pentanedioic acid

PLGA-mPEG5K-LIG
Type Polymer
Formula
Role layer
3

dual drug mixture

Type Complex Compound
Formula
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
human prostatic carcinoma PSMA-overexpressing LNCaP cells

More information available to subscribers only.

Or, view sample content

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. SVJfRYUoEwpB6C93pkt2I5PZqHe
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Diameter: ~ 40 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. wCDT6aGWHs5zY072T9hqj9UTZQ3
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Diameter: ~ 50 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. gYQPKvP8riliQgMqNFcRFiE2KDK
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Diameter: ~ 40 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. 07EWsPolDNe6SUsZyWZLPgwNzRW
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Diameter: ~ 40 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. jwVU4wEJqbutH9XV4TV3Vnma5v2
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Diameter: ~ 40 nm

Medium/Support: none

References

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