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prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Based on

1 Patents
2014 Most recent source

Composition

1

PLGA-mPEG5K

Type Polymer
Formula
Role core
2

poly(lactide-co-glycolic acid)-polyethyleneglycol-S,S-2[3-][5-amino-1-carboxypentyl]-ureido]-pentanedioic acid

PLGA-mPEG5K-LIG
Type Polymer
Formula
Role layer
3

dual drug mixture

Type Complex Compound
Formula
Role loaded material

Properties

Applications

Area Application Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Source
human prostatic carcinoma PSMA-overexpressing LNCaP cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. ezm9qGNmLqVFhrncbYnckpjlp6f
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Method 2

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. i2yBy4UOedTaCRFor7O0nEVPBP6
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Method 3

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. Akb7l0LPFTVmj0eHiiM1wUbW00t
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Method 4

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. dAUEUUCC3AjUgbiNu9T0xtryhz4
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

Method 5

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
See all (4)
  1. fPEZPEwHpikXdfuPG5hLnpAsFji
Product

prostate-specific membrane antigen-targeted cisplatin/irinotecan-loaded nanoparticles

References

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